WebPromotional Article Monitoring. Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database … WebApr 7, 2024 · Mounting evidence supports the crucial role of ferroptosis in tumor suppression. For example, a strong dependence of cancer cells on GPX4 and system Xc- has been noted in multiple types of cancer, and the inhibition of the system Xc- coding gene SLC7A11 induces ferroptotic cell death and enhances cytotoxicity in therapy-resistant …
Regulation of ferroptotic cancer cell death by GPX4 - PubMed
WebFerroptosis is a regulated form of cell death characterized by iron dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, … WebMar 15, 2024 · It has been defined as a new form of programmed cell death (PCD) that differs from other forms of PCD (e.g., apoptosis and necrosis) as it generally exhibits a differential morphology, including cellular swelling with ferroptotic-like nanopores in cytomembranes, an enhanced density of shrunken and fragmentated mitochondria with … flume or weir
Pathophysiology Free Full-Text The Emerging Role of Heat …
WebApr 12, 2024 · We found that hypoxic brain injury led to the upregulation of ptgs2a, ptgs2b (the gene overexpressed in ferroptotic cells and regarded as a marker of ferroptosis), … WebApr 14, 2024 · Yang WS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–31. CAS PubMed PubMed Central Google Scholar DeHart DN, et al. … WebApr 11, 2024 · Ferroptosis is a mode of cell death regulated by iron-dependent lipid peroxidation. Growing evidence suggests ferroptosis induction as a novel anti-cancer … greenfield capital