Cystathionine beta-synthase-like protein

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August undefined, 2024

WebThe gene underlying this phenotype was found to encode a protein containing a putative membrane-localized domain of unknown function (DUF21) and a cystathionine-β … WebApr 10, 2024 · Cystathionine-β-synthase (CBS) is highly expressed in the liver, and deficiencies in Cbs lead to hyperhomocysteinemia (HHCy) and disturbed production of antioxidants such as hydrogen sulfide. We therefore hypothesized that liver-specific Cbs deficient (LiCKO) mice would be particularly susceptible to the development of non …

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WebWe studied the expression of the gene, designated M truncatula Cystathionine-β-Synthase-like1 (MtCBS1), using a promoter-β-glucuronidase gene fusion, which … WebCystathionine β-synthase (CBS) is a key enzyme in the two-step biosynthesis of cysteine from homocysteine and serine and requires vitamin B 6 for its catalysis ( Fig. 39.1 ). This is the only pathway in humans that leads to cysteine production. This pathway competes for homocysteine with homocysteine remethylation by MS in the methyl cycle pathway. imdb the four feathers

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Webcystathionine-beta-synthase ELISA Kits Provided below are ELISA kits targeting cystathionine beta-synthase, a human protein encoded by CBS. This protein is 551 amino acids long with a reported mass of 60.6 kDa. It is also an enzyme classified as a (n) cystathionine beta-synthase. WebOur previous study demonstrated that cystathionine β synthase (CBS) is highly expressed in the cumulus–oocyte complex during ovulation. However, the role of CBS during oocyte maturation remains uncertain. In this study, a small-interfering (si) RNA interference (siRNA) approach was used to investigate the potential role of CBS during oocyte maturation. imdb the flash television

LOC102724560 Gene - Cystathionine Beta-Synthase Like

Cystathionine β-Synthase in Physiology and Cancer - Hindawi

WebHomocystinuria or HCU is an inherited disorder of the metabolism of the amino acid methionine due to a deficiency of cystathionine beta synthase or methionine synthase. It is an inherited autosomal recessive trait, which means a child needs to inherit a copy of the defective gene from both parents to be affected.Symptoms of homocystinuria can also … WebDec 9, 2024 · Many enzymes require pyridoxal 5’-phosphate (PLP) as an essential cofactor and share active site residues in mediating diverse enzymatic reactions. Methionine can be converted into cysteine by cystathionine γ-lyases (CGLs) through a transsulfuration reaction dependent on PLP. In bacteria, MccB, also known as YhrB, exhibits CGL activity … imdb the gabby petito storyWebMar 9, 2024 · Characterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteins. Casique L, et … list of model train manufacturers

"WebNational Center for Biotechnology Information " - Cystathionine beta-synthase-like protein

Cystathionine beta-synthase-like protein

CBS Gene - GeneCards CBS Protein CBS Antibody

WebMutations in the CBS, MTHFR, MTR, MTRR, and MMADHC genes cause homocystinuria.. Mutations in the CBS gene cause the most common form of homocystinuria. The CBS … WebThe CBS gene provides instructions for making an enzyme called cystathionine beta-synthase. This enzyme acts in a chemical pathway and is responsible for using vitamin B6 to convert building block of proteins (amino acid) called homocysteine and serine to a molecule called cytathionine. Another enzyme then converts cystathionine to the amino ...

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WebCystathionine beta-synthase (CBS) is a key regulator of homocysteine metabolism. Although eukaryotic CBS have a similar domain architecture with a catalytic core and a C … WebCystathionine beta-synthase, CBS - a heme protein essential for transsulfuration in mammals, involved in synthesis of cysteine. Deficiency of CBS due to a genetic defect causes homocystinuria in ...

WebWe reveal that, in normoxia, enzymatic action of cystathionine β-synthase (CBS) produces H 2 S, which persulfidates prolyl hydroxylase 2 (PHD2) at residues Cys 21 and Cys 33 (zinc finger motif), augmenting prolyl … WebThe CBS gene provides instructions for making an enzyme called cystathionine beta-synthase. This enzyme acts in a chemical pathway and is responsible for using vitamin …

WebFeb 1, 2012 · However, the pathway of cysteine biosynthesis was interrupted by a reaction catalyzed by the enzyme - cystathionine beta-synthase (CBS), which has no gene assignment in current S. meliloti genome annotation. In addition, production of CBS was observed in the proteomic assay as well . These evidences supported that the CBS … WebBiosynthetically, cystathionine is generated from homocysteine and serine by cystathionine beta synthase (upper reaction in the diagram below). It is then cleaved …

WebCystathionine beta-synthase (CBS) converts HCY to GSH via the transsulfuration pathway with vitamin B6 as cofactor [53–55] ( Fig. 3.2 ). The tripeptide GSH is the main antioxidant and detoxification molecule. Keeping the balance between methylation and transsulfuration depends on methionine levels and allosteric activation of CBS by SAM.

WebSep 9, 2024 · As mentioned above, cystathionine-β-synthase is an enzyme involved in the transsulfuration pathway, which is how the body regulates its levels of sulfur-containing … list of modern conveniencesWebAbstract. The cystathionine-beta-synthase (CBS) domain is an evolutionarily conserved protein domain that is present in the proteome of archaebacteria, prokaryotes, and … list of mobile numberWebMar 29, 2024 · The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. imdb the general\u0027s daughterWebMar 6, 2012 · Certain amino acids, which are the chemical building blocks of proteins, are essential for proper growth and development. In most cases, homocystinuria is caused … imdb the fresh prince of bel airWebFeb 6, 2024 · Cystathionine-β-synthase (CBS) is a modular enzymatic protein of 551 amino acids. The lyase CBS acts in the transsulfuration pathway and has a central role in the mammalian sulfur metabolism by ... imdb the fourth warWebJan 10, 2024 · LOC102724560 (Cystathionine Beta-Synthase Like) is a Protein Coding gene. Among its related pathways are Cysteine formation from homocysteine and One … list of mobility scooters made in the usaWebCystathionine beta-synthase (CBS) converts HCY to GSH via the transsulfuration pathway with vitamin B6 as cofactor [53–55] ( Fig. 3.2). The tripeptide GSH is the main antioxidant and detoxification molecule. Keeping the balance between methylation and transsulfuration depends on methionine levels and allosteric activation of CBS by SAM. list of mobile security antivirus